Crystallization Screening

Crystallization Screening and Development

Often when an API enters into development the solid form is not crystalline. Avista Pharma offers an extensive crystallization service focusing on obtaining a crystalline and easily isolated form of the drug.

 

Our program employs a very large number of crystallization experiments and aims to deliver a process transferable to a scale-up. We also use surface modification technology to encourage crystallization in the most stubborn compounds.

 

Combined with our knowledge of downstream processing, Avista Pharma will deliver a scalable solution.

 

To assess the physical properties of crystalline material we employ the most advanced techniques in solid-state characterization which include:

 

  • X-Ray Powder Diffraction (XRPD)
  • Differential Scanning Calorimetry (DSC)
  • Thermal Gravimetric Analysis (TGA)

 

While also interrogating our materials using a range of developability tests, such as:

 

  • Dynamic Vapor Sorption (DVS)
  • Thermodynamic Solubility
  • Storage Tests

 

Crystallization Dynamics:
This plot shows three important elements of API crystallization.

 

Avista Pharma has a wide expertise in understanding and controlling these dynamics to establish or improve the crystallization of your API for development or scale up purposes.